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US-clinic · historic RxNo approved clinical use

First GH

Stack: Sermorelin · nightly
"The most conservative way into the GH axis. Sermorelin has a real clinical history — the body-composition claims attached to it do not."
GoalConservative GH start
Compounds1 · Sermorelin
Humans exposed (est.)Moderate
StatusMHRA (UK): not a licensed medicine here · FDA (US): Sermorelin historically prescribed; body-comp claims weak
In this stack — snapshot; tap through for the full molecule file
Provenance & evidence layers — of the combination, not the parts
US-clinic
Where / who
Community / athlete and clinic use as tagged above.
Use status
Anti-ageing clinic staple.
Evidence it adds
Popularity / convention — not efficacy.
Basis: real-world uptake & convention — not trial data
US clinic · off-label compounding
Where / who
US functional-medicine, longevity & sports-medicine clinics — physician-prescribed via 503A/503B compounding pharmacies.
Track record
Sermorelin: among the most commonly compounded peptides in US clinics until the Sept 2023 FDA Category 2 listing; removed from Category 2 Apr 2026, 503A Bulks List decision pending the PCAC meeting 23–24 Jul 2026.
Evidence it adds
Real-world clinical observation — physician-charted, supervised use. A genuine evidence tier, but observational: uncontrolled, unpublished, no registry, outside formal pharmacovigilance.
What it means
Off-label compounding under prescription — never an FDA-approved therapy. Removal from Category 2 is not approval.
Basis: US compounding-pharmacy practice · FDA Docket FDA-2025-N-6895
No approved clinical use
Clinical record
No country lists this exact combination as an approved therapy.
Human trials
No completed human trial of the combination. Clinical history; body-comp evidence weak.
Basis required for a clinical-use tag: none found — absence shown, not hidden
Why this combination

Sermorelin is a GHRH analog with a genuine prescribing history. As a starting point it's reasonable; the physique and anti-ageing outcomes commonly attached to it are weakly evidenced.

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Doses, cycle structure and what to monitor are part of membership. The provenance, evidence and exposure above are always free.
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Cycle shape — how it's typically structured, not a schedule to follow
Loading
build up
Maintenance
hold / taper
Off
stop / reassess
Convention from community use, not a prescription. Specific timing is part of membership.
What's worth monitoring

With limited or no human safety data for this combination, there is no established marker set to monitor against — which is a reason for more caution, not less. Baseline bloods and a clinician conversation matter here. General information, not medical advice.

Combination evidence
Real-world uptake Moderate

Anti-ageing clinic staple.

Human efficacy Weak

Clinical history; body-comp evidence weak.

Clinical observation Observational

A decade-plus of physician-supervised, charted use — meaningful real-world signal, with no commonly-reported serious adverse-event pattern. But uncontrolled, unpublished, held in private charts (no registry) and outside formal pharmacovigilance. Not controlled evidence.

The honest ceiling

Real pedigree, oversold outcomes.

Fast facts
Compounds

Sermorelin

Humans exposed (est.)

Moderate.

UK strip

GREEN — research material