Protocols›Metabolic, weight & GH›Metabolic Syndrome
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Has approved analogues · off-label hereUS-clinic · off-labelNo approved clinical use

Metabolic Syndrome

Stack: GLP-1 + AOD-9604 + BPC-157 + NAD⁺ / NMN · weight / metabolic
"A real, strongly-evidenced GLP-1 backbone with a halo of unproven add-ons. The honest split: the GLP-1 works; the peptides bolted onto it are along for the ride."
GoalWeight / metabolic
Compounds4 · GLP-1 + AOD-9604 + BPC-157 + NAD⁺ / NMN
Humans exposed (est.)Very high (GLP-1 class)
StatusMHRA (UK): GLP-1 class are prescription-only medicines · FDA (US): GLP-1 class approved; add-ons not approved · physician-led
In this stack — snapshot; tap through for the full molecule file
Provenance & evidence layers — of the combination, not the parts
Has approved analogues
Where / who
Community / athlete and clinic use as tagged above.
Use status
Tens of millions on licensed GLP-1 versions.
Evidence it adds
Popularity / convention — not efficacy.
Basis: real-world uptake & convention — not trial data
US clinic · off-label compounding
Where / who
US functional-medicine, longevity & sports-medicine clinics — physician-prescribed via 503A/503B compounding pharmacies.
Track record
AOD-9604 / BPC-157: among the most commonly compounded peptides in US clinics until the Sept 2023 FDA Category 2 listing; removed from Category 2 Apr 2026, 503A Bulks List decision pending the PCAC meeting 23–24 Jul 2026.
Evidence it adds
Real-world clinical observation — physician-charted, supervised use. A genuine evidence tier, but observational: uncontrolled, unpublished, no registry, outside formal pharmacovigilance.
What it means
Off-label compounding under prescription — never an FDA-approved therapy. Removal from Category 2 is not approval.
Basis: US compounding-pharmacy practice · FDA Docket FDA-2025-N-6895
No approved clinical use
Clinical record
No country lists this exact combination as an approved therapy.
Human trials
No completed human trial of the combination. Strong for GLP-1; absent for the add-ons.
Basis required for a clinical-use tag: none found — absence shown, not hidden
Why this combination

The GLP-1 class carries large RCT support and is the only part of this stack with strong evidence. The add-ons — AOD-9604, BPC-157, NAD⁺ — do not have outcome data for this use. Honest reading: the backbone is the medicine.

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Cycle shape — how it's typically structured, not a schedule to follow
Loading
build up
Maintenance
hold / taper
Off
stop / reassess
Convention from community use, not a prescription. Specific timing is part of membership.
What's worth monitoring

With limited or no human safety data for this combination, there is no established marker set to monitor against — which is a reason for more caution, not less. Baseline bloods and a clinician conversation matter here. General information, not medical advice.

Combination evidence
Real-world uptake Very high

Tens of millions on licensed GLP-1 versions.

Human efficacy Mixed

Strong for GLP-1; absent for the add-ons.

Clinical observation Observational

A decade-plus of physician-supervised, charted use — meaningful real-world signal, with no commonly-reported serious adverse-event pattern. But uncontrolled, unpublished, held in private charts (no registry) and outside formal pharmacovigilance. Not controlled evidence.

The honest ceiling

Strong core, decorative add-ons — don't confuse the two.

Fast facts
Compounds

GLP-1 · AOD-9604 · BPC-157 · NAD⁺ / NMN

Humans exposed (est.)

Very high (GLP-1 class).

UK strip

AMBER — POM in stack